E7 antibody reagent for histology test (IHC) 
Antibody: Rabbit monoclonal cocktail, 1x working solution 
Packing Size: 3ml, 6ml, 12ml 
Application: IHC test for biopsies or surgical tissue sections for positive expression of E7 protein 
Sample requirement: FFFE (formalin fixed paraffin embedded) tissue slides
Pre-treatment: Antigen retrieval in Citric acid (PH=6.0) buffer 

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Background Information：

Oncogene E6/E7 encoded by the high-risk HPV genome can only express theirgene products, E6 and E7 oncoprotein after the integration of viral genes intothe host (human) genome. Indepth studies and vast research reports haveestablished the oncogenic roles of E6 and E7 protein, and their molecular andcellular mechanisms in tumorigenesis of HPV transformed human host cells. E7protein plays a key role in disrupting the signal pathway of cell cycle,leading to the transformation and tumorigenesis of cervical epithelial cells. Therefore,E6 and E7 protein represent an ideal choice of molecular target for therapeuticsand for cancer diagnosis.

E7 antibody reagent kits (E7-ICC, E7-IHC)offer high specificity and highaffinity for identification of E7 positive cancer cells. Clinical samples treatedwith E7 antibodies via immunochemical methods can be observed under amicroscope for brown stains on cancer cells, allowing a sensitive and more specificidentification of cervical cancer at an early stage, e.g. precancerous lesionsthat can progress to high-grade lesions or cancer.
E7-ICC biomarker test is recommended to use as a primary screening test. It canalso be used to triage patients with HPV-positive results, therefore, reducing doctorreferral rates and unnecessary invasive treatments. A positive E7-ICC resultshould be followed for further diagnosis, such as colposcopy and pathology teston tissue biopsies.